1447699-53-7Relevant articles and documents
A facile green synthesis and anti-cancer activity of bis- arylhydrazononitriles, triazolo[5,1-c][1,2,4]triazine, and 1,3,4-thiadiazolines
Gomha, Sobhi M.,Khalil, Khaled D.,El-Zanaty, Ali M.,Riyadh, Sayed M.
, p. 1109 - 1120 (2013)
Coupling of 2-cyanoacetyl-1-methyl-1H-pyrrole (1) with diazonium salts of 1,4-benzenediamine (2), 2,6-dichlorobenzene-1,4-diamine (4), and benzidine (6) afforded bis-arylhydrazononitriles 3, 5, and 7, respectively. Also, coupling of 1 with [1,2,4]triazole-3-diazonium sulfate (8) gave the respective [1,2,4]triazolo[5,1-c][1,2,4]triazine derivative 11. On the other hands, treatment of 2-[(1-methyl-1H-pyrrol-2-yl)carbonyl]-3-mercapto-3-(phenylamino) acrylonitrile (12) with hydrazonoyl chlorides 13a-h in dioxane, in the presence of chitosan as eco-friendly heterogeneous basic catalyst, under microwave irradiation furnished 1,3,4-thiadiazolines 16a-h, incorporating pyrrole moiety. The anti-cancer activities of the synthesized products were determined against the colon carcinoma (HCT), human laryngeal carcinoma (Hep-2), human medulloblastoma (Daoy), human breast adenocarcinoma (MCF-7), and human colon adenocarcinoma (WiDr) cell lines.
