144782-91-2Relevant academic research and scientific papers
Synthesis of [3H]FPL 64176, a potent calcium channel activator
Foged,Madsen
, p. 659 - 662 (2007/10/02)
Tritium labelled FPL 64176 (1, methyl 2,5-dimethyl-4-(2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate), a potent calcium channel activator with insulinotropic properties was synthesised from the corresponding bromo derivative (3) using tritium gas and Pd/C catalyst. (3) was in turn prepared from methyl 2,5-dimethylpyrrole-3-carboxylate (4) in a one pot procedure. The specific activity of [3H]FPL 64176 was 38 mCi/mmol and radiochemical purity >98%.
An extremely short synthesis of benzoylpyrrole-type calcium channel activators
Dalton, Christopher R.,Kane, John M.,Rampe, David
, p. 5713 - 5716 (2007/10/02)
Friedel-Crafts acylation of methyl 2,5-dimethylpyrrole-3-carboxylate with 2-chloromethylbenzoyl chloride generated the corresponding 4-(2-chloromethylbenzoyl)pyrrole which was reacted in situ with benzene and aluminum chloride to yield the novel calcium c
