1447913-56-5

Basic information

• Product Name: [5-(trifluoromethyl)thiophen-3-yl]methanol
• Synonyms: [5-(trifluoromethyl)thiophen-3-yl]methanol;(5-Trifluoromethyl-Thiophen-3-Yl)-Methanol(WXC00304)
• CAS NO: 1447913-56-5
• Molecular Formula: C6H5F3OS
• Molecular Weight: 182.1635096
• EINECS: -0
• Mol File: 1447913-56-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [5-(trifluoromethyl)thiophen-3-yl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [5-(trifluoromethyl)thiophen-3-yl]methanol(1447913-56-5)
• EPA Substance Registry System: [5-(trifluoromethyl)thiophen-3-yl]methanol(1447913-56-5)

Safety Data

• Hazardous Substances Data: 1447913-56-5(Hazardous Substances Data)

Usage

General Description

[5-(trifluoromethyl)thiophen-3-yl]methanol is a chemical compound with the molecular formula C8H7F3OS. It is a derivative of thiophene, a five-membered heterocyclic compound containing sulfur. The compound contains a trifluoromethyl group and a hydroxyl group attached to the thiophene ring. It is commonly used as an intermediate in organic synthesis for the production of various pharmaceuticals and agrochemicals. The compound has the potential for applications in medicinal chemistry, as well as in the development of new materials and chemical processes. Its unique structure and properties make it a valuable building block for the synthesis of diverse organic compounds.

Upstream product

• 1447913-55-4 methyl 5-(trifluoromethyl)thiophene-3-carboxylate 
• 18895-01-7 5-iodothiophene-3-carboxylic acid 

Relevant articles and documents

Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test

To develop non-basic melanin-concentrating hormone receptor 1 (MCHR1) antagonists with a high probability of target selectivity and therapeutic window, we explored neutral bicyclic motifs that could replace the previously reported imidazo[1,2-a]pyridine or 1H-benzimidazole motif. The results indicated that the binding affinity of a chemically neutral 2H-indazole derivative 8a with MCHR1 (hMCHR1: IC50 = 35 nM) was comparable to that of the imidazopyridine and benzimidazole derivatives (1 and 2, respectively) reported so far. However, 8a was positive in the Ames test using TA1537 in S9- condition. Based on a putative intercalation of 8a with DNA, we introduced a sterically-hindering cyclopropyl group on the indazole ring to decrease planarity, which led to the discovery of 1-(2-cyclopropyl-3-methyl-2H-indazol-5-yl)-4-{[5-(trifluoromethyl)thiophen-3-yl]methoxy}pyridin-2(1H)-one 8l without mutagenicity in TA1537. Compound 8l exerted significant antiobesity effects in diet-induced obese F344 rats and exhibited promising safety profile.

BENZIMIDAZOLE DERIVATIVES AS MCH RECEPTOR ANTAGONISTS

The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula (I) wherein each symbol as defined in the specification, or a salt thereof.