1447946-55-5

Basic information

• Product Name: 3-fluoro-5,6-diphenylbenzo[4,5]imidazo[2,1-a]isoquinoline
• Synonyms: 3-fluoro-5,6-diphenylbenzo[4,5]imidazo[2,1-a]isoquinoline
• CAS NO: 1447946-55-5
• Molecular Weight: 388.444
• Mol File: 1447946-55-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-fluoro-5,6-diphenylbenzo[4,5]imidazo[2,1-a]isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-5,6-diphenylbenzo[4,5]imidazo[2,1-a]isoquinoline(1447946-55-5)
• EPA Substance Registry System: 3-fluoro-5,6-diphenylbenzo[4,5]imidazo[2,1-a]isoquinoline(1447946-55-5)

Safety Data

• Hazardous Substances Data: 1447946-55-5(Hazardous Substances Data)

Upstream product

• 324-27-6 2-(4-fluorophenyl)-1H-benzoimidazole 
• 501-65-5 diphenyl acetylene 
• 21719-77-7 4-fluoro-N-phenylbenzamidine 

Relevant articles and documents

Rhodium(III)-Catalyzed Oxidative Annulation of Amidines with Alkynes via Sequential C?H Bond Activation

In this paper, a rhodium-catalyzed sequential two-fold ortho-C?H functionalization of N-phenylbenzimidamide with internal alkyne is reported. The double C?H activations proved viable in a one-pot fashion with the assistance of C=N and C?N bonds, providing a series of benzimidazoisoquinolines with high levels of positional selectivity control. The operationally simple transformation showed high functional group compatibility and featured the cleavage of C?H bonds located on different a moiety of the N-phenylbenzimidamide substrates. Detailed mechanistic studies provided strong support for C?H bond cleavage on the N-phenyl ring to be preferential compared with C?H bond cleavage on C-phenyl ring. As a multifunctional catalytic platform, the rhodium catalyst conducted two independent and compatible catalytic cycles in one pot.

Ruthenium-catalyzed benzimidazoisoquinoline synthesis via oxidative coupling of 2-arylbenzimidazoles with alkynes

Synthesis of a fused bis-heterocyclic framework, benzimidazoisoquinoline, has been achieved using Ru-catalyzed reaction of alkynes with 2-aryl benzimidazoles in the presence of Cu salts. The method provides an easy access for the generation of a library of benzimidazoisoquinoline derivatives.