1447946-83-9

Upstream product

• 1447946-78-2 phenyl 4-O-acetyl-2-azido-2-deoxy-6-O-t-butyldiphenylsilyl-1-thio-β-D-galactopyranoside 
• 1447946-72-6 phenyl 3-O-acetyl-6-O-t-butyldiphenylsilyl-1-thio-β-D-mannopyranoside 
• 246875-56-9 phenyl 6-O-tert-butyldiphenylsilyl-1-thio-β-D-mannopyranoside 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 77481-63-1 phenyl-1-thio-β-D-mannopyranoside 
• 1447946-82-8 N-(benzyloxycarbonyl)-O-(4-O-acetyl-2-azido-3-O-chloroacetyl-2-deoxy-6-O-t-butyldiphenylsilyl-α-D-galactopyranosyl)-L-serine methyl ester 
• 1447946-79-3 phenyl 4-O-acetyl-2-azido-3-O-chloroacetyl-2-deoxy-6-O-t-butyldiphenylsilyl-1-thio-β-D-galactopyranoside 

Relevant academic research and scientific papers

Total synthesis of MECA-79

The MECA-79 antigen is a sulfated mucin type core-1 extended O-glycan which is a potential anti-inflammatory agent. Herein we report a total synthesis of MECA-79 via a convergent [2 + 2] glycosylation route. The synthesis relies on efficient transformation of d-glucosamine into the orthogonally protected Tn antigen derivative and its elaboration into the TF antigen en route to MECA-79. This journal is

Orthogonally protected d-galactosamine thioglycoside building blocks via highly regioselective, double serial and double parallel inversions of β-d-thiomannoside

An efficient route for the synthesis of orthogonally protected d-galactosamine thioglycosides via one-pot double serial and double parallel displacements of the d-mannosyl-2,4-bis-trifluoromethanesulfonates by azide and nitrite ions is described. These bu