1447966-48-4

Basic information

• Product Name: ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(3-methylphenyl)amino]thiazol-5-yl}acetate
• Synonyms: ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(3-methylphenyl)amino]thiazol-5-yl}acetate
• CAS NO: 1447966-48-4
• Molecular Weight: 435.503
• Mol File: 1447966-48-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(3-methylphenyl)amino]thiazol-5-yl}acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(3-methylphenyl)amino]thiazol-5-yl}acetate(1447966-48-4)
• EPA Substance Registry System: ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(3-methylphenyl)amino]thiazol-5-yl}acetate(1447966-48-4)

Safety Data

• Hazardous Substances Data: 1447966-48-4(Hazardous Substances Data)

Upstream product

• 65706-98-1 ethyl 5-(1,3-dioxoisoindolin-2-yl)-4-oxopentanoate 
• 1074-82-4 potassium phtalimide 
• 621-40-9 (3-methylphenyl)thiourea 
• 1447966-39-3 ethyl 3-bromo-5-(1,3-dioxoisoindolin-2-yl)-4-oxopentanoate 
• 539-88-8 4-oxopentanoic acid ethyl ester 

Downstream Products

• 1447966-56-4 2-{4-aminomethyl-2-[(3-methylphenyl)amino]thiazol-5-yl}acetic acid 

Relevant articles and documents

Synthesis of thiazole derivatives bearing an incorporated Z-5-aminopent-3-enoic acid fragment

Novel compounds bearing a joint thiazole and a Z-5-aminopent-3-enoic acid fragments have been synthesized from readily accessible 5-bromolevulinic esters through a sequence of nucleophilic substitution, bromination, Hantzsch-type heterocyclization and Gabriel-like deprotection reactions. A majority of these reactions proceed in ionic liquid media that enhances their efficiency and selectivity in comparison to the corresponding reactions in conventional organic solvents. The compounds have a significant pharmaceutical potential.