1448-16-4Relevant articles and documents
Catalytic, asymmetric transannular aldolizations: Total synthesis of (+)-hirsutene
Chandler, Carley L.,List, Benjamin
, p. 6737 - 6739 (2008/12/22)
We report an asymmetric, catalytic transannular aldolization that provides polycyclic products useful for natural product synthesis. We found that a proline-derivative catalyzes the transannular aldol reaction of 1,4-cyclooctanediones to the corresponding cyclic β-hydroxy ketones in good yields and with high enantioselectivities. The utility of our reaction has been demonstrated in a total synthesis of (+)-hirustene. Copyright