1448-52-8

Basic information

• Product Name: N,N-BIS(2-CHLOROETHYL)-4-METHOXYANILINE
• Synonyms: N,N-BIS(2-CHLOROETHYL)-4-METHOXYANILINE;N,N-Bis(2-chloroethyl)-4-methoxybenzenamine
• CAS NO: 1448-52-8
• Molecular Formula: C₁₁H₁₅Cl₂NO
• Molecular Weight: 0
• Mol File: 1448-52-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 360.1°Cat760mmHg
• Flash Point: 171.6°C
• Appearance: /
• Density: 1.197g/cm³
• Vapor Pressure: 2.26E-05mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: N,N-BIS(2-CHLOROETHYL)-4-METHOXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-BIS(2-CHLOROETHYL)-4-METHOXYANILINE(1448-52-8)
• EPA Substance Registry System: N,N-BIS(2-CHLOROETHYL)-4-METHOXYANILINE(1448-52-8)

Safety Data

• Hazardous Substances Data: 1448-52-8(Hazardous Substances Data)

Usage

General Description

N,N-BIS(2-CHLOROETHYL)-4-METHOXYANILINE is a chemical compound that belongs to the class of bis(chloroethyl)amines. It is a highly toxic and carcinogenic compound that is commonly used as a chemical intermediate in the production of dyes and textiles. Exposure to this chemical can cause severe irritation to the skin, eyes, and respiratory tract, as well as long-term health effects such as cancer and reproductive toxicity. It is important to handle this chemical with extreme caution and to use appropriate safety measures when working with it. Additionally, proper disposal and storage of this chemical are essential to prevent environmental contamination and harm to human health.

InChI:InChI=1/C11H15Cl2NO/c1-15-11-4-2-10(3-5-11)14(8-6-12)9-7-13/h2-5H,6-9H2,1H3

Upstream product

• 104-94-9 4-methoxy-aniline 
• 107-04-0 1-Bromo-2-chloroethane 
• 19721-54-1 2-[(2-hydroxyethyl)-(4-methoxyphenyl)amino]ethanol 

Downstream Products

• 19721-54-1 2-[(2-hydroxyethyl)-(4-methoxyphenyl)amino]ethanol 
• 27347-14-4 N-(4-methoxyphenyl)morpholine 
• 875245-98-0 N,N-bis-(2-iodo-ethyl)-p-anisidine 
• 110195-98-7 4-(4-methoxy-phenyl)-thiomorpholine 
• 24867-52-5 N,N-bis-(2-benzoyloxy-ethyl)-p-anisidine 
• 1452855-74-1 4,4'-((((4-methoxyphenyl)azanediyl)bis(ethane-2,1-diyl))bis(oxy))diphenol 
• 1268821-26-6 3-benzoyl-9-(4-methoxyphenyl)-3,9-diaza-6-azoniaspiro[5.5]undecane chloride 
• 1268821-11-9 1-methyl-1-benzyl-4-(4-methoxyphenyl)piperazin-1-ium chloride 
• 1268821-08-4 4-(4-methoxyphenyl)-1,1-dimethylpiperazin-1-ium chloride 
• 1268821-09-5 1,1-dibutyl-4-(4-methoxyphenyl)piperazin-1-ium chloride 
• 1268821-27-7 4'-(4-methoxyphenyl)spiro[indoline-1,1'-piperazin]-1-ium chloride 
• 1268821-14-2 3-(4-methoxyphenyl)-3-aza-6-azoniaspiro[5.6]dodecane chloride 
• 1268821-16-4 9-(4-methoxyphenyl)-2,4-dimethyl-3-oxa-9-aza-6-azoniaspiro[5.5]undecane chloride 
• 1268821-21-1 3-(4-methoxyphenyl)-9-methyl-3,9-diaza-6-azoniaspiro[5.5]undecane chloride 

Relevant articles and documents

Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies

Malaria deaths have been decreasing over the last 10-15 years, with global mortality rates having fallen by 47% since 2000. While the World Health Organization (WHO) recommends the use of artemisinin-based combination therapies (ACTs) to combat malaria, the emergence of artemisinin resistant strains underscores the need to develop new antimalarial drugs. Recent in vivo efficacy improvements of the historical antimalarial ICI 56,780 have been reported, however, with the poor solubility and rapid development of resistance, this compound requires further optimization. A series of piperazine-containing 4(1H)-quinolones with greatly enhanced solubility were developed utilizing structure-activity relationship (SAR) and structure-property relationship (SPR) studies. Furthermore, promising compounds were chosen for an in vivo scouting assay to narrow selection for testing in an in vivo Thompson test. Finally, two piperazine-containing 4(1H)-quinolones were curative in the conventional Thompson test and also displayed in vivo activity against the liver stages of the parasite.

A new disubstituted polyacetylene bearing DDTC moieties: Postfunctional synthetic strategy, selective and sensitive chemosensor towards mercury ions

A new DDTC-functionalized disubstituted polyacetylene (P2) with strong green fluorescence was successfully synthesized by utilizing the postfunctional method. The polymer was soluble in common organic solvents, and its strong green fluorescence could be q

Synthesis of 1-[3-methyl-2(3H)-benzazolon-5- or 6-yl]-4-{4-[cis-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl-methyl)-1, 3-dioxolan-4-yl]methyleneoxyphenyl]}piperazines

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