1448-52-8

Usage

Uses

Used in Chemical Intermediates Industry:
N,N-BIS(2-CHLOROETHYL)-4-METHOXYANILINE is used as a chemical intermediate for the production of dyes and textiles, contributing to the coloration and quality of these products. Its role in this industry is crucial, despite the inherent risks associated with its use, due to its effectiveness in enhancing the characteristics of the final products.
Used in Safety and Environmental Management:
Given its high toxicity and carcinogenic nature, N,N-BIS(2-CHLOROETHYL)-4-METHOXYANILINE is also a key focus in the development and implementation of safety protocols and environmental management strategies. Its use necessitates the establishment of stringent safety measures to protect workers from exposure and to prevent environmental contamination, thereby ensuring the health and safety of both individuals and ecosystems.

InChI:InChI=1/C11H15Cl2NO/c1-15-11-4-2-10(3-5-11)14(8-6-12)9-7-13/h2-5H,6-9H2,1H3

Upstream product

• 19721-54-1 2-[(2-hydroxyethyl)-(4-methoxyphenyl)amino]ethanol 
• 104-94-9 4-methoxy-aniline 
• 107-04-0 1-Bromo-2-chloroethane 

Downstream Products

• 24867-52-5 N,N-bis-(2-benzoyloxy-ethyl)-p-anisidine 
• 110195-98-7 4-(4-methoxy-phenyl)-thiomorpholine 
• 875245-98-0 N,N-bis-(2-iodo-ethyl)-p-anisidine 
• 859964-70-8 4-cyano-1-(4-methoxyphenyl)-4-phenylpiperidine 
• 19721-54-1 2-[(2-hydroxyethyl)-(4-methoxyphenyl)amino]ethanol 
• 15018-73-2 1-(4-methoxyphenyl)-4-phenylpiperazine 
• 38869-05-5 N-(4-methoxyphenyl)-N'-methylpiperazine 
• 68104-68-7 [4-(4-methoxy-phenyl)-piperazin-1-yl]-acetic acid ethyl ester 
• 150916-76-0 1,3-dimethyl-5-<4-(4-methoxyphenyl)-1-piperazinyl>-2(3H)-benzimidazolone 
• 82819-79-2 N,N-di<2-(o-2-hydroxyethoxyphenyloxy)ethyl>-p-anisidine 
• 150916-71-5 3-methyl-6-<4-(4-methoxyphenyl)-1-piperazinyl>-2(3H)-benzoxazolone 

Relevant academic research and scientific papers

Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies

Malaria deaths have been decreasing over the last 10-15 years, with global mortality rates having fallen by 47% since 2000. While the World Health Organization (WHO) recommends the use of artemisinin-based combination therapies (ACTs) to combat malaria, the emergence of artemisinin resistant strains underscores the need to develop new antimalarial drugs. Recent in vivo efficacy improvements of the historical antimalarial ICI 56,780 have been reported, however, with the poor solubility and rapid development of resistance, this compound requires further optimization. A series of piperazine-containing 4(1H)-quinolones with greatly enhanced solubility were developed utilizing structure-activity relationship (SAR) and structure-property relationship (SPR) studies. Furthermore, promising compounds were chosen for an in vivo scouting assay to narrow selection for testing in an in vivo Thompson test. Finally, two piperazine-containing 4(1H)-quinolones were curative in the conventional Thompson test and also displayed in vivo activity against the liver stages of the parasite.

ROS-Activated Compounds as Selective Anti-Cancer Therapeutics

Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer therapeutics for cancers associated with elevated ROS. Also provided are methods and pharmaceutical compositions for treating cancers associated with increased ROS.

A new disubstituted polyacetylene bearing DDTC moieties: Postfunctional synthetic strategy, selective and sensitive chemosensor towards mercury ions

A new DDTC-functionalized disubstituted polyacetylene (P2) with strong green fluorescence was successfully synthesized by utilizing the postfunctional method. The polymer was soluble in common organic solvents, and its strong green fluorescence could be q

Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable NR2R3 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via π-π interaction. Introduction of substituting group on the N4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 μM/kg, sc) and holds promise for development as a mechanically new analgesic drug.

Hypoxia-Selective Antitumor Agents. 3. Relationships between Structure and Cytotoxicity against Cultured Tumor Cells for Substituted N,N-Bis(2-chloroethyl)anilines

A series of aniline mustards with a wide range of electron-donating and -withdrawing substituents in the 3- and 4-positions has been synthesized and evaluated for cytotoxicity in cell culture to examine the potential of using nitro group deactivated nitrogen mustards for the design of novel hypoxia-selective anticancer drugs (Denny, W.A.; Wilson, W.R.J.Med Chem. 1986, 29, 879).Hydrolytic half-lives in tissue culture media, determined by bioassay against a cell line (UV4) defective in the repair of DNA interstrand cross-links showed the expected dependence on the Hammett electronic parameter, ?, varying from 0.13 h for the 4-amino analogue to >100 h for analogues with strongly electron-withdrawing substituents.Cytotoxic potencies in aerobic UV4 cultures showed a similar dependence on ?.This dependence predicted that the 4-nitroaniline mustard would be 7200-fold less potent than its potential six-electron reduction product, the 4-amino compound, in growth inhibition assays using a 1-h drug exposure.The measured differential was much lower (225-fold) because of the instability of the latter compound, but a differential of 17500-fold was observed in the initial rate of killing by using a clonogenic assay.The potential for formation of reactive mustards by reduction to the amine or hydroxylamine was demonstrated by the 4-nitroso compound, which had an aerobic toxicity similar to that of the amine.Although these features confirmed the original rationale, the 3-nitro- and 4-nitroaniline mustards had only minimal hypoxic selectivity against UV cells.Toxicity to hypoxic cells appears to be limited by the low reduction potentials of these compounds and consequent lack of enzymatic nitroreduction.However, this study has demonstrated that nitro groups can be used to latentiate aromatic nitrogen mustards and indicates that examples with higher reduction potentials could provide useful hypoxia-selective therapeutic agents.