1448005-50-2Relevant academic research and scientific papers
Synthesis of 5-(2-hydroxybenzoyl)-1,3-disubstituted uracils
Talhi, Oualid,Pinto, Diana C. G. A.,Silva, Artur M. S.
, p. 1147 - 1149 (2013/06/27)
A new synthesis of novel nucleoside analogues is reported. These 5-(2-hydroxybenzoyl)-1,3-disubstituted uracils have been prepared by the coupling of chromone-3-carboxylic acid with carbodiimides, leading to 3-chromone-N-acylureas, which underwent organocatalyzed N-cyclization and chromone ring opening. In the case of ditolylcarbodiimide, the corresponding uracil was obtained by a one-pot, uncatalyzed reaction with chromone-3- carboxylic acid. Georg Thieme Verlag Stuttgart New York.
