1448013-96-4Relevant academic research and scientific papers
(2 S)-2-[(Phenylsulfinyl)methyl]pyrrolidine-catalyzed efficient stereoselective michael addition of cyclohexanone and cyclopentanone to nitroolefins
Singh, Kamalnain,Singh, Paramjit,Kaur, Amarjit,Singh, Pushpinder,Sharma, Sandeepkumar,Khullar, Sadhika,Mandal, Sanjay K.
, p. 1406 - 1413 (2013)
(2S)-2-[(Phenylsulfinyl)methyl]pyrrolidine, derived from l-proline, has been demonstrated as an efficient organocatalyst for the asymmetric Michael addition of cyclohexanone and cyclopentanone to β-nitrostyrenes. This pyrrolidine-based catalyst bearing a sulfoxide moiety was used to synthesize various γ-nitro carbonyl compounds in high yield (up to 97%) with excellent stereoselectivity (up to >99:1 dr and >99% ee) without the use of any additive.
