1448014-02-5Relevant academic research and scientific papers
Pyrrolidine-carbamate based new and efficient chiral organocatalyst for asymmetric Michael addition of ketones to nitroolefins
Kaur, Amarjit,Singh, Kamal Nain,Sharma, Esha,Shilpy,Rani, Poonam,Sharma, Sandeep Kumar
, p. 6137 - 6143 (2018/09/29)
The novel ((S)-pyrrolidin-2-yl)methyl phenylcarbamate was synthesized and used as an efficient organocatalyst for the asymmetric Michael addition of cyclic/acyclic ketones to nitroolefins. Interestingly, the resulting Michael adducts were obtained in good to high yields (up to 96%) with excellent stereoselectivity (ee up to >99%, dr up to >99:1) without using any additive.
(2 S)-2-[(Phenylsulfinyl)methyl]pyrrolidine-catalyzed efficient stereoselective michael addition of cyclohexanone and cyclopentanone to nitroolefins
Singh, Kamalnain,Singh, Paramjit,Kaur, Amarjit,Singh, Pushpinder,Sharma, Sandeepkumar,Khullar, Sadhika,Mandal, Sanjay K.
, p. 1406 - 1413 (2013/07/05)
(2S)-2-[(Phenylsulfinyl)methyl]pyrrolidine, derived from l-proline, has been demonstrated as an efficient organocatalyst for the asymmetric Michael addition of cyclohexanone and cyclopentanone to β-nitrostyrenes. This pyrrolidine-based catalyst bearing a sulfoxide moiety was used to synthesize various γ-nitro carbonyl compounds in high yield (up to 97%) with excellent stereoselectivity (up to >99:1 dr and >99% ee) without the use of any additive.
