1448019-80-4Relevant articles and documents
Asymmetric synthesis of 1-aza-4-deoxypicropodophyllotoxin
Aigret, Benoit M.,Jacobs, Jeroen,Van Meervelt, Luc,De Borggraeve, Wim M.
, p. 1097 - 1100 (2013/06/27)
In our search for new easily accessible analogues based on the natural product podophyllotoxin, we synthesized 1-aza-4-deoxypicropodophyllotoxin in good overall yield and excellent enantioselectivity. The synthesis was centered around a direct asymmetric Mannich reaction using d-proline as the key step for introduction of the chiral centres. Our synthesis of 1-aza-4- deoxypodophyllotoxin was hindered through the increased instability towards epimerization of the C2 position. We did, however, synthesized a new scaffold based on the opened lactone analogue. Georg Thieme Verlag Stuttgart New York.
