1448021-11-1

Basic information

• Product Name: C₂₇H₃₄FN₃O₈
• CAS NO: 1448021-11-1
• Molecular Weight: 547.581
• Mol File: 1448021-11-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₄FN₃O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₄FN₃O₈(1448021-11-1)
• EPA Substance Registry System: C₂₇H₃₄FN₃O₈(1448021-11-1)

Safety Data

• Hazardous Substances Data: 1448021-11-1(Hazardous Substances Data)

Upstream product

• 7304-32-7 2-fluoro-5-nitrobenzoic acid 
• 20781-20-8 2,4-Dimethoxybenzylamine 
• 15586-32-0 1,1-diethoxy-2-isocyanoethane isocyanide 
• 1489-69-6 Cyclopropanecarboxaldehyde 

Relevant articles and documents

Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade

Dihydropyrazino-quinazolinedione chemotypes are complex and structurally challenging structures of biological interest, being found in the marine alkaloids such as brevianamide M-N and fumiquinazolines A-C. Herein we report the synthesis of this tricyclic system in three synthetic operations by means of an Ugi multi-component reaction (MCR) followed by a tandem N-acyliminium ion cyclization-intramolecular nucleophilic addition reaction sequence. Additional structural diversification for further library enrichment was also accomplished via sequential N-alkylation and N-acylation/sulfonation.