1448024-20-1Relevant academic research and scientific papers
Approach to trisubstituted 1 H -pyrroles from alkynoates and amines mediated by tert -butyl perbenzoate
Liu, Weibing,Tan, Liquan,Zhou, Peng,Chen, Cui,Zhang, Qing
, p. 991 - 994 (2013)
A simple and concise tandem cyclization of alkynoates with amines in the presence of tert-butyl perbenzoate (TBPB) leads to 1,2,4-trisubstituted 1H-pyrroles. A variety of aromatic amines and aliphatic amines can be used in this approach, and a wide range of functionalized 1,2,4-trisubstituted 1H-pyrroles are obtained in good to excellent yields. This protocol not only corresponds to the construction of a pyrrole fragment, but also provides a new way to form C-C and C-N bonds. Georg Thieme Verlag Stuttgart . New York.
