1448026-32-1

Basic information

• Product Name: methyl 2-methylnaphtho[1,2-d]oxazole-4-carboxylate
• Synonyms: methyl 2-methylnaphtho[1,2-d]oxazole-4-carboxylate
• CAS NO: 1448026-32-1
• Molecular Weight: 241.246
• Mol File: 1448026-32-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-methylnaphtho[1,2-d]oxazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-methylnaphtho[1,2-d]oxazole-4-carboxylate(1448026-32-1)
• EPA Substance Registry System: methyl 2-methylnaphtho[1,2-d]oxazole-4-carboxylate(1448026-32-1)

Safety Data

• Hazardous Substances Data: 1448026-32-1(Hazardous Substances Data)

Upstream product

• 288402-18-6 methyl 3-(trifluoromethanesulfonyloxy)naphthalene-2-carboxylate 
• 10576-12-2 ethyl acetohydroximate 

Relevant articles and documents

Synthesis and evaluation of an O-Aminated naphthol AS-E as a prodrug of CREB-mediated gene transcription inhibition

An O-Aminated naphthol AS-E was designed as a prodrug to achieve reductive activation and improved aqueous solubility. During the synthesis of this designed compound, a novel transformation from aryl triflates and ethyl acetohydroximate to oxazoles was discovered. Although the initially designed O-Amino naphthol AS-E was not made successfully, the eventually synthesized O-tert-butylamino derivative was found to be biologically inactive, suggesting that reductive N-O cleavage in this compound was not facile due to unfavorable steric and electronic effects.