1448032-52-7Relevant articles and documents
Selective sequential cross-coupling reactions on imidazole towards neurodazine and analogues
Recnik, Lisa-Maria,Abd El Hameid, Mohammed,Haider, Maximilian,Schnuerch, Michael,Mihovilovic, Marko D.
, p. 1387 - 1405 (2013/07/05)
Polysubstituted imidazoles represent a common structural motif in bioactive molecules. A modular and flexible strategy towards 2,4,5-triarylated imidazoles is reported applying a Suzuki-Miyaura cross-coupling protocol. Employing 1-protected 2,4,5-tribromoimidazole as starting material, both stepwise and one-pot protocols towards the title compounds are disclosed. The utility of the approach was demonstrated by synthesizing neurodazine, a biologically active molecule affecting neuronal cell differentiation.