1448074-13-2Relevant academic research and scientific papers
A simple and efficient one-pot synthesis of 4-alkyl-3,4-dihydropyrimidin- 2(1H)-ones
Kolosov, Maksim A.,Kulyk, Olesia G.,Beloborodov, Dmitriy A.,Orlov, Valeriy D.
, p. 115 - 118 (2013)
4-Alkyl-3,4-dihydropyrimidin-2(1H)-ones possess a number of important properties in comparison with their 4-aryl analogues. We show that these compounds can be synthesised by a simple one-pot reaction of urea or thiourea, different aliphatic aldehydes (from acetaldehyde to valeraldehyde) and various dicarbonyl compounds (ethyl acetoacetate, pentane-2,4-dione, N-(4-chlorophenyl)-3-oxobutanamide, acetoacetaldehyde dimethylacetal) in refluxing DMF or HOAc without use of any catalyst. The methylation of 4-alkyl-5-C(O)R-3,4-dihydropyrimidin-2(1H)-ones leads to 1-methyl derivatives.
