144809-98-3Relevant articles and documents
A convenient synthesis of new 2-peptidylimino[1, 3]thiazin-4-ones
Yadav,Shukla, Supriya,Saigal, Sandhya
, p. 102 - 105 (2007/10/03)
Michael addition of sulphur nucleophiles, N-aryldithiocarbamic acids (2a, b) to 4-arylidene-5(4H)-oxazolones (1a, b) followed by ring transformation of the resultant Michael adducts (3a-d) yields 3, 6-diaryl-5-benzamido-2-thioxoperhydro[1, 3]thiazin-4-ones (4a-d) in a one-pot procedure. Compounds 4a-d have been converted to the corresponding bis(3, 6-diaryl-5-benzamido-2-ethylthio-4-oxoperhydro[1, 3]thiazin-2-ylium) sulphates (5a-d). 5a-d undergo addition-elimination with nitrogen nucleophiles, such as peptides (gly.gly and gly.L-ala) to give the new 3, 6-diaryl-5-benzamido-2-peptidylimino[1, 3]thiazin-4-ones (7a-h). The compounds 4, 5 and 7 have been compared with a commercial fungicide, Dithane M-45, for their fungitoxicity against A. solani and F. oxysporum.