1448147-55-4Relevant academic research and scientific papers
Synthesis and characterization of a novel near-infrared fluorescent probe for living cells imaging
Ji, Min,Sun, Chunlong,Wang, Zhe,Xing, Jing
, p. 668 - 672 (2020)
Currently, optical probes with near-infrared (NIR) fluorescence are of great interest in chemical biology. In the present study, we designed and synthesized a novel NIR fluorescent probe, IR789. IR789 has high selectivity and sensitivity for living cells imaging. The stronger excitation and emission characteristics suggested its dominant optical properties over ICG. IR789 also showed a high affinity and inconspicuous cytotoxicity at the cellular level. The results of fluorescent image in living A549 cells (human lung adenocarcinoma epithelial cell line) further demonstrated its potential applications for biomedical diagnosis in biological systems utilization of nanotechnology.
Heptamethine cyanine near-infrared fluorescent molecular probe and preparation method and application thereof
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Paragraph 0035-0037; 0043-0044; 0048-0049, (2017/08/27)
The invention discloses a heptamethine cyanine near-infrared fluorescent molecular probe and a preparation method and application thereof. The structure of the near-infrared fluorescent molecular probe is as shown in the formula (V). The preparation method includes the following steps: allowing 2,3,3-trimethyl-3H-indoline-5-sulfonate to react with p-nitrobenzylbromide in an organic solvent under the protection of inert gases to obtain a compound shown in the formula (III); allowing the compound shown in the formula (III) to react with 2-chlorine-1-formyl-2-hydroxymethyl cyclohexene in an organic solvent under the protection of inert gases to obtain a compound shown in the formula (V). The invention further discloses the application of the near-infrared fluorescent molecular probe in living cell imaging. The near-infrared fluorescent molecular probe is novel in structure, can enhance the fluorescence intensity and improves the cell imaging effect.
DYE COMPOSITIONS, METHODS OF PREPARATION, CONJUGATES THEREOF, AND METHODS OF USE
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, (2013/07/31)
Dye compounds of the formula (1) wherein A is a protective agent group that has a characteristic of modifying the singlet-triplet occupancy of the shown cyanine moiety, and M is a reactive crosslinking group or a group that can be converted to a reactive crosslinking group. Methods for synthesizing the dye compounds and applications for their use are also described.
