1448151-09-4Relevant academic research and scientific papers
Transformation of 3-(3-arylalkylcarbamoyl-4-hydroxy-2-oxo-1,2- dihydroquinolin-1-yl)propanenitriles into amides and acids
Ukrainets,Gorokhova,Andreeva
, p. 867 - 871 (2013)
A mixture of hydrochloric and acetic acids depleted in water was proposed to effect stepwise transformation of 3-(3-arylalkylcarbamoyl-4-hydroxy-2-oxo-1, 2-dihydroquinolin-1-yl)propanenitriles into the corresponding amides and then into the acids. The procedure turned out to be efficient with 3-[(2-phenylethyl)-carbamoyl] derivatives, whereas the reactions with benzylcarbamoyl analogs were accompanied by partial or complete debenzylation.
