1448168-14-6Relevant articles and documents
Multicomponent synthesis of antibacterial dihydropyridin and dihydropyran embelin derivatives
Pena, Rosalyn,Jimenez-Alonso, Sandra,Feresin, Gabriela,Tapia, Alejandro,Mendez-Alvarez, Sebastian,Machin, Felix,Ravelo, Angel G.,Estevez-Braun, Ana
, p. 7977 - 7985 (2013/09/12)
A series of dihydropyran and dihydropyridin embelin derivatives were synthesized through a novel and straightforward one-pot protocol based on a three-component reaction with embelin, aldehydes, and cyclic enaminones as synthetic imputs. The type of substituent on the nitrogen atom of the β-enaminone is key to obtain nitrogenated or oxygenated rings. The obtained compounds were active against Gram-positive bacteria, including multiresistant Staphylococcus aureus clinical isolates.
