1448186-49-9

Basic information

• Product Name: C₂₃H₂₄N₄O₄
• Synonyms: C₂₃H₂₄N₄O₄
• CAS NO: 1448186-49-9
• Molecular Weight: 420.468
• Mol File: 1448186-49-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₄N₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₄N₄O₄(1448186-49-9)
• EPA Substance Registry System: C₂₃H₂₄N₄O₄(1448186-49-9)

Safety Data

• Hazardous Substances Data: 1448186-49-9(Hazardous Substances Data)

Upstream product

• 672324-91-3 [4-(1,3-oxazol-5-yl)phenyl]methanamine 
• 268729-12-0 (2S,4R)-4-tert-butoxy-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid 

Relevant articles and documents

Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin Ligase

The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins that are degraded and/or otherwise inhibited by bifunctional compounds of the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand that binds to the ubiquitin ligase and on the other end a moiety that binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds of the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α

By design: Novel small-molecule inhibitors of the interaction between the von Hippel-Lindau ligase (VHL) and its molecular target HIF1α, a transcription factor involved in oxygen sensing, have been developed and studied. The most potent inhibitor binds with an IC50 value of 0.9-μM and is thus the first sub-micromolar inhibitor of the VHL-HIF1α interaction. Copyright