144824-87-3Relevant academic research and scientific papers
Lithiation Substitution of Unprotected Benzyltetrazoles
Wong, Jeff Y. F.,Lewandowska, Agnieszka,Trowse, Benjamin R.,Barker, Graeme
, p. 7069 - 7072 (2019)
1H-Tetrazoles occupy an important role in modern medicinal chemistry, but few methods for their modification exist. Many extant protocols require the use of a difficult to remove N-alkyl-protecting group, precluding the products from use as carboxylate bioisosteres, the major role of tetrazoles in pharmaceuticals. We herein report a convenient, protecting-group-free lithiation-substitution protocol for benzylic tetrazoles. Metalation with n-BuLi at 0 °C followed by electrophilic trapping gave a range of α-functionalized benzyltetrazoles in up to 91% yield.
KHMDS mediated synthesis of 9-arylfluorenes from dibenzothiophene dioxides and arylacetonitriles by tandem SNAr-decyanation-based arylation
Mylavarapu, Saketh,Yadav, Mamta,Bhanuchandra
supporting information, p. 7815 - 7819 (2018/11/21)
A straightforward KHMDS mediated synthetic route to 9-arylfluorenes from readily available starting materials has been developed. This reaction involves SNAr reactions of dioxide with arylacetonitriles, followed by decyanation reaction. The pro
NOVEL HETEROCYCLIC COMPOUNDS HAVING PLATELET AGGREGATION INHIBITORY EFFECTS
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, (2008/06/13)
Disclosed are a compound represented by the following formula (I) and pharmacologically acceptable salt and solvate thereof having inhibitory activity against platelet aggregation: ???wherein A represents the following formula (II), (III), or (IV): A phar
N-(3-pyridylalkyl)sulfonamide compounds which have useful pharmaceutical activity
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, (2008/06/13)
Illustrative examples of the N-(3-pyridylalkyl)sulfonamide derivative are represented by the following formulae [II] and [III]: STR1 The derivatives are available for a thromboxane A2 production inhibitor, a thromboxane A2 antagonist, a prostaglandin H2 antagonist, an anti-thrombus agent, a thrombus-preventing agent and an anti-allergy agent.
