1448261-83-3Relevant academic research and scientific papers
Copper-Catalyzed Synthesis of β- And δ-Carbolines by Double N-Arylation of Primary Amines
Van Phuc, Ban,Do, Ha Nam,Quan, Nguyen Minh,Tuan, Nguyen Ngoc,An, Nguyen Quang,Van Tuyen, Nguyen,Anh, Hoang Le Tuan,Hung, Tran Quang,Dang, Tuan Thanh,Langer, Peter
, p. 1004 - 1008 (2021/04/12)
Two efficient and practical approaches are reported for the synthesis of β- and δ-carbolines from 3,4-dibromopyridine. The synthesis is based on site-selective Cu-catalyzed double C-N coupling reactions and subsequent annulations by twofold Pd-catalyzed C-N coupling with amines.
Efficient access to β- and γ-carbolines from a common starting material by sequential site-selective Pd-catalyzed C–C, C–N coupling reactions
Hung, Tran Quang,Hieu, Do Trung,Van Tinh, Dinh,Do, Ha Nam,Nguyen Tien, Tuan Anh,Van Do, Dang,Son, Le Thanh,Tran, Ngoc Han,Van Tuyen, Nguyen,Tan, Vu Minh,Ehlers, Peter,Dang, Tuan Thanh,Langer, Peter
, (2019/09/07)
Two efficient and practical approaches are reported for the synthesis of β- and γ-carboline derivatives from 3,4-dibromopyridine as a common starting material. The β-carbolines were prepared by site-selective Pd-catalyzed C–C coupling with o-bromophenylboronic acid and subsequent cyclization by double C–N coupling with amines. γ-Carbolines were prepared from the same starting material by C–N coupling with anilines and subsequent annulation by domino C–C/C–N coupling with o-bromophenylboronic acid.
Synthesis and structure-activity relationships of N2-alkylated quaternary β-carbolines as novel antitumor agents
Zhang, Guoxian,Cao, Rihui,Guo, Liang,Ma, Qin,Fan, Wenxi,Chen, Xuemei,Li, Jianru,Shao, Guang,Qiu, Liqin,Ren, Zhenghua
, p. 21 - 31 (2013/10/01)
A series of novel N2-alkylated quaternary β-carbolines was synthesized by modification of position-1, 2, 7 and 9 of β-carboline nucleus with various alkyl and arylated alkyl substituents, and their cytotoxic activities in vitro and antitumor potencies in mice were evaluated. Compound 3m was found to be the most potent antitumor agent. SARs analysis revealed that (1) the substituents in position-2 and 9 of β-carboline nucleus played a vital role in modulation of antitumor activity; (2) the benzyl and 3-phenylpropyl substituents in position-2 and 9 of β-carboline ring were the optimal substituents giving rise to significant antitumor agent. These compounds might be a novel promising class of antitumor agents with clinical development potential.
