14483-99-9 Usage
Molecular Structure
1H-Benzimidazole, 2-(4,5-dihydro-2-oxazolyl)-(9CI) consists of a benzene ring fused to an imidazole ring and a 2-(4,5-dihydro-2-oxazolyl) side group.
Classification
It is a chemical compound and a derivative of benzimidazole.
Pharmacological Activities
1H-Benzimidazole, 2-(4,5-dihydro-2-oxazolyl)-(9CI) has potential pharmacological activities and is being studied for its potential applications in drug development and medicinal chemistry.
Research Status
Additional research and studies are needed to fully understand the properties and potential uses of 1H-Benzimidazole, 2-(4,5-dihydro-2-oxazolyl)-(9CI).
Check Digit Verification of cas no
The CAS Registry Mumber 14483-99-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,4,8 and 3 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 14483-99:
(7*1)+(6*4)+(5*4)+(4*8)+(3*3)+(2*9)+(1*9)=119
119 % 10 = 9
So 14483-99-9 is a valid CAS Registry Number.
14483-99-9Relevant articles and documents
2-(4,5-Dihydroimidazol-2-yl)benzimidazoles as highly selective imidazoline I2/adrenergic α2 receptor ligands
Saczewski, Francieszek,Tabin, Piotr,Tyacke, Robin J.,Maconie, Alys,Saczewski, Jaroslaw,Kornicka, Anita,Nutt, David J.,Hudson, Alan L.
, p. 6679 - 6685 (2007/10/03)
2-(4,5-Dihydroimidazol-2-yl)benzimidazoles have been identified as selective imidazoline I2/α2-adrenoceptor ligands. 4-Methyl (2) and 4-chloro (4) derivatives display I2 affinity at nanomolar concentration (Ki = 4.4 and 17.7 nM, respectively) and high I2/α2 selectivity ratio = 4226 and 5649, respectively. An evidence has been obtained that pKa value influences considerably the I2/α2-selectivity ratio of this class of imidazoline I2 receptor ligands.