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1448307-66-1

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1448307-66-1 Usage

Description

1-(2-chloropyriMidin-4-yl)-3-Methyl-1H-pyrazole-4-carbaldehyde is a pyrazole derivative with the molecular formula C9H8ClN5O. It features a chloropyrimidine group and a carbaldehyde functional group, making it a versatile compound in the fields of organic synthesis and medicinal chemistry.

Uses

Used in Organic Synthesis:
1-(2-chloropyriMidin-4-yl)-3-Methyl-1H-pyrazole-4-carbaldehyde is used as a building block for the synthesis of various heterocyclic compounds and organic materials. Its unique structure and properties allow for the creation of new pharmaceuticals and biologically active molecules.
Used in Medicinal Chemistry:
In the pharmaceutical industry, 1-(2-chloropyriMidin-4-yl)-3-Methyl-1H-pyrazole-4-carbaldehyde is utilized as an intermediate for the development of novel drugs. Its potential biological activities and pharmacological effects are being studied, although further research is required to fully explore its applications in this field.

Check Digit Verification of cas no

The CAS Registry Mumber 1448307-66-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,8,3,0 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1448307-66:
(9*1)+(8*4)+(7*4)+(6*8)+(5*3)+(4*0)+(3*7)+(2*6)+(1*6)=171
171 % 10 = 1
So 1448307-66-1 is a valid CAS Registry Number.

1448307-66-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-chloropyrimidin-4-yl)-3-methylpyrazole-4-carbaldehyde

1.2 Other means of identification

Product number -
Other names 1-(2-Chloropyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carbaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1448307-66-1 SDS

1448307-66-1Downstream Products

1448307-66-1Relevant articles and documents

Optimization of a series of potent, selective and orally bioavailable SYK inhibitors

Balazs, Amber,Barlaam, Bernard,Boiko, Scott,Dowling, James E.,Dry, Hannah,Edmondson, Scott D.,Fawell, Stephen,Gingipalli, Lakshmaiah,Goldberg, Frederick W.,Grimster, Neil P.,Ikeda, Timothy P.,Impastato, Anna C.,Jones, Natalie H.,Kawatkar, Sameer,Kemmitt, Paul,Lamont, Scott,Patel, Joe,Pike, Andy,Read, Jon,Sarkar, Ujjal,Sha, Li,Shao, Wenlin,Simpson, Iain,Su, Qibin,Tomlinson, Ronald C.,Wang, Haixia,Wang, Haiyun,Wang, Lianghe,Wang, Peng,Watson, David,Wilson, David M.,Zehnder, Troy E.,Zheng, XiaoLan

supporting information, (2020/08/21)

Spleen tyrosine kinase (SYK) is a non-receptor cytosolic kinase. Due to its pivotal role in B cell receptor and Fc-receptor signaling, inhibition of SYK has been targeted in a variety of disease areas. Herein, we report the optimization of a series of potent and selective SYK inhibitors, focusing on improving metabolic stability, pharmacokinetics and hERG inhibition. As a result, we identified 30, which exhibited no hERG activity but unfortunately was poorly absorbed in rats and mice. We also identified a SYK chemical probe, 17, which exhibits excellent potency at SYK, and an adequate rodent PK profile to support in vivo efficacy/PD studies.

SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS

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Paragraph 0218; 0219, (2015/04/28)

Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).

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