1448307-66-1

Basic information

• Product Name: 1-(2-chloropyriMidin-4-yl)-3-Methyl-1H-pyrazole-4-carbaldehyde
• Synonyms: 1-(2-chloropyriMidin-4-yl)-3-Methyl-1H-pyrazole-4-carbaldehyde;1-(2-Chloro-4-pyrimidinyl)-3-methyl-1H-pyrazole-4-carboxaldehyde
• CAS NO: 1448307-66-1
• Molecular Formula: C₉H₇ClN₄O
• Molecular Weight: 222.63108
• EINECS: -0
• Mol File: 1448307-66-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-(2-chloropyriMidin-4-yl)-3-Methyl-1H-pyrazole-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloropyriMidin-4-yl)-3-Methyl-1H-pyrazole-4-carbaldehyde(1448307-66-1)
• EPA Substance Registry System: 1-(2-chloropyriMidin-4-yl)-3-Methyl-1H-pyrazole-4-carbaldehyde(1448307-66-1)

Safety Data

• Hazardous Substances Data: 1448307-66-1(Hazardous Substances Data)

Usage

Description

1-(2-chloropyriMidin-4-yl)-3-Methyl-1H-pyrazole-4-carbaldehyde is a pyrazole derivative with the molecular formula C9H8ClN5O. It features a chloropyrimidine group and a carbaldehyde functional group, making it a versatile compound in the fields of organic synthesis and medicinal chemistry.

Uses

Used in Organic Synthesis:
1-(2-chloropyriMidin-4-yl)-3-Methyl-1H-pyrazole-4-carbaldehyde is used as a building block for the synthesis of various heterocyclic compounds and organic materials. Its unique structure and properties allow for the creation of new pharmaceuticals and biologically active molecules.
Used in Medicinal Chemistry:
In the pharmaceutical industry, 1-(2-chloropyriMidin-4-yl)-3-Methyl-1H-pyrazole-4-carbaldehyde is utilized as an intermediate for the development of novel drugs. Its potential biological activities and pharmacological effects are being studied, although further research is required to fully explore its applications in this field.

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 112758-40-4 3-methyl-1H-pyrazole-4-carbaldehyde 

Relevant articles and documents

Optimization of a series of potent, selective and orally bioavailable SYK inhibitors

Spleen tyrosine kinase (SYK) is a non-receptor cytosolic kinase. Due to its pivotal role in B cell receptor and Fc-receptor signaling, inhibition of SYK has been targeted in a variety of disease areas. Herein, we report the optimization of a series of potent and selective SYK inhibitors, focusing on improving metabolic stability, pharmacokinetics and hERG inhibition. As a result, we identified 30, which exhibited no hERG activity but unfortunately was poorly absorbed in rats and mice. We also identified a SYK chemical probe, 17, which exhibits excellent potency at SYK, and an adequate rodent PK profile to support in vivo efficacy/PD studies.

SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS

Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).