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CAS

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1448338-15-5

N2-(4-aminocyclohexyl)-N6-[6-(2-aminophenyl)pyridin-3-ylmethyl]-9-cyclopentyl-9H-purine-2,6-diamine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1448338-15-5 Structure

  • Basic information

    1. Product Name: N2-(4-aminocyclohexyl)-N6-[6-(2-aminophenyl)pyridin-3-ylmethyl]-9-cyclopentyl-9H-purine-2,6-diamine
    2. Synonyms: N2-(4-aminocyclohexyl)-N6-[6-(2-aminophenyl)pyridin-3-ylmethyl]-9-cyclopentyl-9H-purine-2,6-diamine
    3. CAS NO:1448338-15-5
    4. Molecular Formula:
    5. Molecular Weight: 497.646
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1448338-15-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N2-(4-aminocyclohexyl)-N6-[6-(2-aminophenyl)pyridin-3-ylmethyl]-9-cyclopentyl-9H-purine-2,6-diamine(CAS DataBase Reference)
    10. NIST Chemistry Reference: N2-(4-aminocyclohexyl)-N6-[6-(2-aminophenyl)pyridin-3-ylmethyl]-9-cyclopentyl-9H-purine-2,6-diamine(1448338-15-5)
    11. EPA Substance Registry System: N2-(4-aminocyclohexyl)-N6-[6-(2-aminophenyl)pyridin-3-ylmethyl]-9-cyclopentyl-9H-purine-2,6-diamine(1448338-15-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1448338-15-5(Hazardous Substances Data)

1448338-15-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1448338-15-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,8,3,3 and 8 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1448338-15:
(9*1)+(8*4)+(7*4)+(6*8)+(5*3)+(4*3)+(3*8)+(2*1)+(1*5)=175
175 % 10 = 5
So 1448338-15-5 is a valid CAS Registry Number.

1448338-15-5Downstream Products

1448338-15-5Relevant articles and documents

2-SUBSTITUTED-6-BIARYLMETHYLAMINO-9-CYCLOPENTYL-9H-PURINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS

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Paragraph 0119; 0120, (2016/03/08)

This invention relates to novel 2-substituted-6-biarylmethylamino-9-cyclopentyl-9H-purine derivatives, showing activity as specific inhibitors of growth and angiogenesis of hepatocellular carcinoma. The invention further includes pharmaceutical compositions containing the 2-substituted-6-biarylmethylamino-9-cyclopentylpurines.

A novel series of highly potent 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitors

Gucky, Tomá?,Jorda, Radek,Zatloukal, Marek,Bazgier, Václav,Berka, Karel,?ezní?ková, Eva,Béres, Tibor,Strnad, Miroslav,Kry?tof, Vladimír

, p. 6234 - 6247 (2013/09/02)

The inhibition of overactive CDKs during cancer remains an important strategy in cancer drug development. We synthesized and screened a novel series of 2-substituted-6-biarylmethylamino-9-cyclopentylpurine derivatives for improved CDK inhibitory activity and antiproliferative effects. One of the most potent compounds, 6b, exhibited strong cytotoxicity in the human melanoma cell line G361 that correlated with robust CDK1 and CDK2 inhibition and caspase activation. In silico modeling of 6b in the active site of CDK2 revealed a high interaction energy, which we believe is due to the 6-heterobiarylmethylamino substitution of the purine moiety.

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