1448355-79-0Relevant academic research and scientific papers
Dynamic Carbon Isotope Exchange of Pharmaceuticals with Labeled CO2
Destro, Gianluca,Loreau, Olivier,Marcon, Elodie,Taran, Frédéric,Cantat, Thibault,Audisio, Davide
supporting information, p. 780 - 784 (2019/01/11)
A copper-catalyzed procedure enabling dynamic carbon isotope exchange is described. Utilizing the universal precursor [14C]CO2, this protocol allows to insert, in one single step, the desired carbon tag into carboxylic acids with no need of structural modifications. Reducing synthetic costs and limiting the generation of radioactive waste, this procedure will facilitate the access to carboxylic acids containing drugs and accelerate early 14C-based ADME studies supporting drug development.
Copper-catalyzed decarboxylation of aromatic carboxylic acids: En route to milder reaction conditions
Cahiez, Gerard,Moyeux, Alban,Gager, Olivier,Poizat, Mael
supporting information, p. 790 - 796 (2013/04/10)
The copper-catalyzed decarboxylation of carboxylic aromatic acids has been advantageously achieved by using aliphatic amines like tetramethylethylenediamine (TMEDA) or hexamethylenetetraamine (HMTA) as ligands instead of the aromatic heterocyclic amines (quinoline, phenanthroline) used until now. The improvement is significant since the reaction can be performed at a lower temperature (ca. 50 °C less) and the reaction time is clearly shorter (15 min instead of 12 to 24 h). Copyright
