1448438-51-4

Basic information

• Product Name: (1S,2S)-2-hydroxycyclooctyl 3-phenylpropanoate
• Synonyms: (1S,2S)-2-hydroxycyclooctyl 3-phenylpropanoate
• CAS NO: 1448438-51-4
• Molecular Weight: 276.376
• Mol File: 1448438-51-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2S)-2-hydroxycyclooctyl 3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-2-hydroxycyclooctyl 3-phenylpropanoate(1448438-51-4)
• EPA Substance Registry System: (1S,2S)-2-hydroxycyclooctyl 3-phenylpropanoate(1448438-51-4)

Safety Data

• Hazardous Substances Data: 1448438-51-4(Hazardous Substances Data)

Upstream product

• 51075-28-6 2-bromo-3-phenylpropanal 
• 42565-22-0 trans-1,2-cyclooctanediol 

Relevant articles and documents

Enhanced rate and selectivity by carboxylate salt as a basic cocatalyst in chiral N-heterocyclic carbene-catalyzed asymmetric acylation of secondary alcohols

The rate and enantioselectivity of chiral NHC-catalyzed asymmetric acylation of alcohols with an adjacent H-bond donor functionality are remarkably enhanced in the presence of a carboxylate cocatalyst. The degree of the enhancement is correlated with the basicity of the carboxylate. With a cocatalyst and a newly developed electron-deficient chiral NHC, kinetic resolution and desymmetrization of cyclic diols and amino alcohols were achieved with extremely high selectivity (up to s = 218 and 99% ee, respectively) at a low catalyst loading (0.5 mol %). This asymmetric acylation is characterized by a unique preference for alcohols over amines, which are not converted into amides under the reaction conditions.