1448443-63-7Relevant academic research and scientific papers
Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents
Hadi, Victor,Hotard, Megan,Ling, Taotao,Salinas, Yandira G.,Palacios, Gustavo,Connelly, Michele,Rivas, Fatima
, p. 376 - 380 (2013)
Protozoal diseases such as malaria are a leading world health concern. We screened a library of fractionated natural products to identify new potential therapeutic leads and discovered that jatrophone (a product of Jatropha isabelli) exerts significant activity against Plasmodium falciparum strains 3D7 and K1. A focused jatrophone-scaffold library was synthesized to evaluate jatrophone's mode of action and identify more selective analogs. Compounds 25 and 32 of this natural product-inspired compound library exhibited micromolar EC50 values against strains 3D7 and K1, thus providing a new antimalarial molecular scaffold. Our report describes an efficient derivatization approach used to evaluate the structure-activity relationship of jatrophone analogs in search of potential new antimalarial agents.
