1448465-33-5

Basic information

• Product Name: 15-(4-methoxyphenyl)naphth[1,2-e][1,3]oxazino[2,3-a]isoquinoline
• Synonyms: 15-(4-methoxyphenyl)naphth[1,2-e][1,3]oxazino[2,3-a]isoquinoline
• CAS NO: 1448465-33-5
• Molecular Weight: 393.485
• Mol File: 1448465-33-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 15-(4-methoxyphenyl)naphth[1,2-e][1,3]oxazino[2,3-a]isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 15-(4-methoxyphenyl)naphth[1,2-e][1,3]oxazino[2,3-a]isoquinoline(1448465-33-5)
• EPA Substance Registry System: 15-(4-methoxyphenyl)naphth[1,2-e][1,3]oxazino[2,3-a]isoquinoline(1448465-33-5)

Safety Data

• Hazardous Substances Data: 1448465-33-5(Hazardous Substances Data)

Upstream product

• 3230-65-7 3,4-dihydroisoquinoline 
• 1158402-27-7 1-amino-(4-methoxyphenyl)methyl-2-naphthol hydrochloride 

Relevant articles and documents

Unexpected isomerization of new naphth[1,3]oxazino[2,3-a]isoquinolines in solution, studied by dynamic NMR and supported by theoretical DFT computations

Through the reactions of 1-aminomethyl-2-naphthol and substituted 1-aminobenzyl-2-naphthols with 3,4-dihydroisoquinoline or 6,7-dimethoxy-3,4- dihydroisoquinoline under microwave conditions, naphth-[1,2-e][1,3]oxazino[2,3- a]-isoquinoline derivatives were prepared in good yields. The latter reaction was extended by using 2-aminoarylmethyl-1-naphthols, leading to isomeric naphth-[2,1-e][1,3]oxazino[2,3-a]isoquinolines. Beside the detailed NMR spectroscopic and theoretical study of both stereochemistry and dynamic behaviour of these new conformational flexible heterocyclic ring systems an unexpected dynamic process between two diastereomers was observed in solution, studied by variable temperature 1H NMR spectroscopy and the mechanism proved by theoretical DFT computations.