1448512-87-5

Basic information

• Product Name: S-(+)-N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine tartrate
• Synonyms: S-(+)-N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine tartrate
• CAS NO: 1448512-87-5
• Molecular Weight: 455.508
• Mol File: 1448512-87-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: S-(+)-N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine tartrate(CAS DataBase Reference)
• NIST Chemistry Reference: S-(+)-N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine tartrate(1448512-87-5)
• EPA Substance Registry System: S-(+)-N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine tartrate(1448512-87-5)

Safety Data

• Hazardous Substances Data: 1448512-87-5(Hazardous Substances Data)

Upstream product

• 81402-52-0 3-(dimethylamino)-3-phenylpropan-1-ol 
• 147-71-7 D-tartaric acid 
• 321-38-0 1-Fluoronaphthalene 

Downstream Products

• 1071929-03-7 Dapoxetine hydrochloride 
• 119356-77-3 dapoxetine 

Relevant articles and documents

A S - west reaches anchors the sandbank and its salt synthesis method

The invention discloses a synthetic method for S-dapoxetine. The synthetic method comprises the following steps: (1) resolving 1-phenyl-3-(naphthyl-1-oxy)propylamine for at least once with a resolving agent to obtain a resolved mixed system; (2) separating the resolved mixed system to obtain S-1-phenyl-3-(naphthyl-1-oxy)propylamine, and recycling mother liquor; (3) performing methylation on the S-1-phenyl-3-(naphthyl-1-oxy)propylamine to obtain S-dapoxetine. Compared with the conventional industrial production method, residual intermediate (R)-phenyl-3-(naphthyl-1-oxy)propylamine in the resolved mother liquor is firstly recycled on the basis of the prior art, then resolved again through D-(-) tartaric acid after racemization, and recycled, so that the yield is increased, the product waste is avoided, and the economic benefits are improved.