1448604-40-7Relevant academic research and scientific papers
Synthesis of nitrogen bridgehead heterocycles with phosphonates via a novel tandem process
Xie, Ya-Fei,Ge, Yan-Qing,Feng, Lei,Xu, Hua-Qiang,Meng, Song,Zhao, Gui-Long,Xu, Wei-Ren,Jia, Jiong,Wang, Jian-Wu
, p. 815 - 826 (2013/05/08)
A novel and efficient method was developed for the synthesis of nitrogen bridgehead heterocycles with phosphonates. Nitrogen containing five-membered heterocyclic aldehyde and diethyl 3-bromoprop-1- enylphosphonate were used as substrates. Bridgehead nitrogen-containing arylphosphonates were obtained via one-pot reaction including four steps: SN2, deprotonation followed by electron flow, nucleophic additon and elimination of water.
