1448609-91-3Relevant academic research and scientific papers
Synthesis and in vitro cellular uptake of 11C-labeled 5-aminolevulinic acid derivative to estimate the induced cellular accumulation of protoporphyrin IX
Suzuki, Chie,Kato, Koichi,Tsuji, Atsushi B.,Kikuchi, Tatsuya,Zhang, Ming-Rong,Arano, Yasushi,Saga, Tsuneo
supporting information, p. 4567 - 4570 (2013/08/23)
Protoporphyrin IX (PpIX) accumulation induced by exogenous 5-aminolevulinic acid (ALA) in tumors affects the therapeutic efficacy of ALA-based photodynamic and sonodynamic therapies. To develop a new imaging probe to estimate the ALA-induced PpIX accumulation, 11C-labeled ALA analog (4), an ALA-dehydratase inhibitor, was radiosynthesized via 11C-methylation of a Schiff-base-activated precursor in the presence of tetrabutylammonium fluoride, followed by the hydrolysis of ester and imine groups. The cellular uptake of 4 linearly increased with time and was inhibited by ALA and other transporter competitors. Monitoring analog 4 with positron emission tomography might be useful to estimate the ALA-induced PpIX accumulation in tumors.
