1448620-97-0Relevant academic research and scientific papers
Efficient intramolecular cyclizations of phenoxyethynyl diols into multisubstituted α,β-unsaturated lactones
Egi, Masahiro,Ota, Yuya,Nishimura, Yuka,Shimizu, Kaori,Azechi, Kenji,Akai, Shuji
supporting information, p. 4150 - 4153 (2013/09/12)
AgOTf-catalyzed intramolecular cyclization of phenoxyethynyl diols proceeded under mild conditions to afford the multisubstituted α,β-unsaturated-γ-lactones in 55-98% yields. This method was also applicable to the synthesis of α,β-unsaturated-δ-lactones. A similar cyclization proceeded when AgOTf was replaced with a stoichiometric amount of N-bromosuccinimide to furnish the α-bromo-substituted α,β-unsaturated lactones.
