1448631-52-4

Basic information

• Product Name: C₂₀H₁₆ClN₃O₂S
• CAS NO: 1448631-52-4
• Molecular Weight: 397.885
• Mol File: 1448631-52-4.mol

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₆ClN₃O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₆ClN₃O₂S(1448631-52-4)
• EPA Substance Registry System: C₂₀H₁₆ClN₃O₂S(1448631-52-4)

Safety Data

• Hazardous Substances Data: 1448631-52-4(Hazardous Substances Data)

Upstream product

• 1448631-44-4 C₂₄H₂₅ClN₂O₃S 
• 1019115-42-4 methyl 2-bromo-4,5-dimethylthiophene-3-carboxylate 
• 14559-13-8 methyl 4,5-dimethylthiophene-3-carboxylate 
• 1380089-34-8 (3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazol-5-yl)methyl acetate 
• 1448631-51-3 methyl 2-(5-formyl-3-methylisoxazol-4-yl)-4,5-dimethylthiophene-3-carboxylate 
• 1472673-29-2 (1S)-3-(tert-butoxy)-1-(4-(3-(methoxycarbonyl)-4,5-dimethylthiophen-2-yl)-3-methylisoxazol-5-yl)-3-oxopropan-1-aminium chloride 
• 1380088-18-5 2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-isoxazolo[5,4-c]thieno[2,3-e]azepin-6-yl)acetic acid 
• 1448631-48-8 methyl 2-(5-((S)-3-(tert-butoxy)-1-((S)-1,1-dimethylethylsulfinamido)-3-oxopropyl)-3-methylisoxazol-4-yl)-4,5-dimethylthiophene-3-carboxylate 
• 1380089-74-6 tert-butyl 2-((6S)-4-chloro-2,3,9-trimethyl-6H-isoxazolo[5,4-c]thieno[2,3-e]azepin-6-yl)acetate 

Downstream Products

• 1380088-40-3 methyl (((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-isoxazolo[5,4-c]thieno[2,3-e]azepin-6-yl)methyl)carbamate 
• 1448631-54-6 C₁₉H₁₈ClN₃OS 

Relevant articles and documents

Discovery, design, and optimization of isoxazole azepine BET inhibitors

The identification of a novel series of small molecule BET inhibitors is described. Using crystallographic binding modes of an amino-isoxazole fragment and known BET inhibitors, a structure-based drug design effort lead to a novel isoxazole azepine scaffold. This scaffold showed good potency in biochemical and cellular assays and oral activity in an in vivo model of BET inhibition.