1448632-87-8

Upstream product

• 5707-04-0 Phenylselenyl chloride 
• 1427442-05-4 C₂₄H₂₅NO₄ 
• 85382-90-7 methyl-4,5,7,8-tetra-O-acetyl-2,6-anhydro-2,3-dideoxy-D-manno-oct-2-enosonat 

Downstream Products

• 1427442-06-5 C₄₁H₄₇NO₁₅ 
• 1427442-07-6 2-(4-(2-aminoethoxy)benzyl)-3-deoxy-α-D-manno-oct-2-ulopyranosidonic acid 

Relevant academic research and scientific papers

TOTAL SYNTHESIS AND IMMUNOLOGICAL EVALUATION OF SACCHARIDE MOIETIES OF THE LIPOPOLYSACCHARIDE FROM NEISSERIA MENINGITIDIS

The present invention relates to the total chemical synthesis of the monosaccharide 35# (R' = H), the disaccharide 36# (R' ≠ H; R'' = H), the trisaccharide 37# (R' ≠ H; R'' ≠ H; R''' = H) and the tetrasaccharide 1#(R' ≠ H; R'' ≠ H; R''' ≠ H) of the following general formula wherein R represents –Y–NH2 Y represents a linker R' is H or R'' is H or R''' is H or of the lipopolysaccharide from Neisseria meningitidis, as well as to the trisaccharide 37# and the tetrasaccharide 1#, to vaccines containing at least one of the saccharides 1#, 35#, 36#, and 37# and to the use of such vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide α-GlcNAc-(1→2)-α- Hep-(1→3)-α-Hep-(1→5)-α-Kdo or the trisaccharide α-Hep-(1→3)-α-Hep-(1→5)-α- Kdo or α-GlcNAc-(1→2)-α-Hep-(1→3)-α-Hep, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.