1448633-62-2Relevant academic research and scientific papers
Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators
Kubas, Holger,Meyer, Udo,Krueger, Bjoern,Hechenberger, Mirko,Vanejevs, Maksims,Zemribo, Ronalds,Kauss, Valerjans,Ambartsumova, Raisa,Pyatkin, Ilya,Polosukhin, Alexey I.,Abel, Ulrich
supporting information, p. 4493 - 4500 (2013/08/23)
A virtual screening approach using various in silico methodologies led to the discovery of 2-(m-tolylamino)-7,8-dihydroquinazolin-5(6H)-one (1) as a moderately active negative allosteric modulator (NAM) of the metabotropic glutamate receptor subtype 5 (mGluR5) showing high selectivity against the subtype mGluR1. Modifications of the parent compound by rational design yielded a series of highly potent derivatives which will serve as valuable starting points for further hit-to-lead optimization efforts toward a suitable drug candidate for the treatment of l-DOPA induced dyskinesia.
