1448668-53-8

Basic information

• Product Name: [¹³C₆]-4-nitroanisole
• Synonyms: [¹³C₆]-4-nitroanisole
• CAS NO: 1448668-53-8
• Molecular Weight: 159.071
• Mol File: 1448668-53-8.mol

Chemical Properties

• CAS DataBase Reference: [¹³C₆]-4-nitroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: [¹³C₆]-4-nitroanisole(1448668-53-8)
• EPA Substance Registry System: [¹³C₆]-4-nitroanisole(1448668-53-8)

Safety Data

• Hazardous Substances Data: 1448668-53-8(Hazardous Substances Data)

Upstream product

• 152571-52-3 anisole-1,2,3,4,5,6-¹³C₆ 

Downstream Products

• 718613-16-2 [¹³C₆]-p-anisidine 

Relevant articles and documents

NITRATION OF AROMATIC COMPOUNDS

The present invention provides a process for nitrating aromatic compounds without the need for a solid catalyst and/or any organic solvents and/or any other additives. A typical process includes combining or admixing a nitric acid and an anhydride compound under conditions sufficient to produce a reactive intermediate. The aromatic compound to be nitrated is then added to this reactive intermediate to produce a nitroaromatic compound. The nitroaromatic compound can be substituted with one or more, typically, one to three, and often one or two nitrate (-NO2) groups.

Synthesis of 13C and 15N labeled 2,4-dinitroanisole

Syntheses of [13C6]-2,4-dinitroanisole (ring- 13C6) from [13C6]-anisole (ring-13C6) and [15N2]-2,4- dinitroanisole from anisole using in situ generated acetyl nitrate and [ 15N]-acetyl nitrate, respectively, are described. Treatment of [ 13C6]-anisole (ring-13C6) with acetyl nitrate generated in 100% HNO3 gave [13C 6]-2,4-dinitroanisole (ring-13C6) in 83% yield. Treatment of anisole with [15N]-acetyl nitrate generated in 10 N [15N]-HNO3 gave [15N2]-2,4- dinitroanisole in 44% yield after two cycles of nitration. Byproducts in the latter reaction included [15N]-2-nitroanisole and [ 15N]-4-nitroanisole.

Synthesis of [13C6]primaquine

In support of a program to identify toxic metabolites of the antimalarial, primaquine, its [13C6] analog was prepared from [ 13C6] anisole in seven steps. Copyright