1448680-35-0Relevant academic research and scientific papers
Palladium-Catalyzed Enantioselective Alkoxycarbonylation of Propargylic Carbonates with (R)- or (S)-3,4,5-(MeO)3-MeOBIPHEP
Zhang, Wanli,Ma, Shengming
, p. 8590 - 8595 (2017)
(R)- and (S)-3,4,5-(MeO)3-MeOBIPHEP have been identified as the efficient chiral ligands for the palladium-catalyzed highly enantioselective synthesis of 2,3-allenoates from different types of easily available racemic propargylic carbonates wit
A room-temperature catalytic asymmetric synthesis of allenes with ECNU-Phos
Wang, Yuli,Zhang, Wanli,Ma, Shengming
supporting information, p. 11517 - 11520 (2013/09/02)
Three-carbon axial chirality has been asymmetrically established from racemic one-carbon central chirality efficiently at room temperature: we report here the discovery of the first catalytic asymmetric carbonylation of readily available racemic propargylic carbonates to access optically active 2,3-allenoates with fairly high ee. The combination of [(π-allyl)PdCl] 2 with [(R)-ECNU-Phos], a new chiral bisphosphine ligand based on a biphenyl skeleton, demonstrates high enantioselectivity. Both enantiomers of allenoates can be obtained at room temperature by applying either (R)- or (S)-ECNU-Phos.
