1448687-38-4Relevant articles and documents
Synthesis and the 5-HT6 receptor antagonistic effect of 3-arylsulfonylamino-5,6-dihydro-6-substituted pyrazolo[3,4]pyridinones for neuropathic pain treatment
Devegowda, Vani Nelamane,Hong, Jin-Ri,Cho, Sungjin,Lim, Eun Jeong,Choo, Hyunah,Keum, Gyochang,Rhim, Hyewon,Nam, Ghilsoo
, p. 4696 - 4700 (2013/08/23)
A novel series of 3-arylsulfonylamino-5,6-dihydro-6-substituted-1H- pyrazolo[3,4-c]pyridine-7-ones was designed and synthesized as 5-HT6 ligands. Among the derivatives synthesized, the lead compound, 12b, having piperidine functionality at the 6-position and (1-naphthyl)sulfonamino at the 3-position of the core structure showed the most potent 5-HT6 inhibitory activity in vitro, good stability without CYP liability, and good neuropathic pain alleviation activity in a rat animal model.