1448705-03-0

Basic information

• Product Name: C₁₃H₁₁F₅N₄O
• CAS NO: 1448705-03-0
• Molecular Weight: 334.249
• Mol File: 1448705-03-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₁F₅N₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₁F₅N₄O(1448705-03-0)
• EPA Substance Registry System: C₁₃H₁₁F₅N₄O(1448705-03-0)

Safety Data

• Hazardous Substances Data: 1448705-03-0(Hazardous Substances Data)

Upstream product

• 42601-04-7 3,4-difluorophenyl isocyanate 
• 1174850-85-1 3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-amine 

Relevant articles and documents

Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors

This letter describes a multi-dimensional SAR campaign based on a potent, efficacious and selective GIRK1/2 activator (～10-fold versus GIRK1/4 and inactive on nonGIRK 1-containing GIRKs, GIRK 2 or GIRK2/3). Further chemical optimization through an iterative parallel synthesis effort identified multiple 'molecular switches' that modulated the mode of pharmacology from activator to inhibitor, as well as engendering varying selectivity profiles for GIRK1/2 and GIRK1/4. Importantly, these compounds were all inactive on nonGIRK1 containing GIRK channels. However, SAR was challenging as subtle structural modifications had large effects on both mode of pharmacology and GIRK1/2 and GIRK1/4 channel selectivity.