1448724-91-1

Basic information

• Product Name: 2-methyl-5-(4-nitrophenyl)-3-phenylfuran
• Synonyms: 2-methyl-5-(4-nitrophenyl)-3-phenylfuran
• CAS NO: 1448724-91-1
• Molecular Weight: 279.295
• Mol File: 1448724-91-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-methyl-5-(4-nitrophenyl)-3-phenylfuran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-5-(4-nitrophenyl)-3-phenylfuran(1448724-91-1)
• EPA Substance Registry System: 2-methyl-5-(4-nitrophenyl)-3-phenylfuran(1448724-91-1)

Safety Data

• Hazardous Substances Data: 1448724-91-1(Hazardous Substances Data)

Upstream product

• 866562-23-4 1-phenyl-3-(trimethylsilyl)prop-2-yn-1-yl acetate 
• 100-19-6 (4-nitrophenyl)ethanone 
• 24037-94-3 2-Phenyl-1-buten-3-on-oxim-methylaether 
• 555-16-8 4-nitrobenzaldehdye 
• 32123-84-5 3-phenylbut-3-en-2-one 

Relevant articles and documents

One-pot synthesis of 2-methylfurans from 3-(trimethylsilyl)propargyl acetates promoted by trimethylsilyl trifluoromethanesulfonate

In the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) and triethylamine, 3-(trimethylsilyl)propargyl carboxylates undergo a one-pot alkylation-cyclization-desilylation reaction with ketones to produce 2-methylfurans. Alkylation at 0 °C in methylene chloride, followed by acid-catalyzed cyclization at room temperature, provides the furans in 52–86% yield. Cyclization and desilylation appear to be promoted by triflic acid generated in situ from the exposure of the reaction mixture to water upon completion of the initial substitution reaction.