144874-45-3Relevant academic research and scientific papers
Preparation of Neplanocin-A from D-Ribose and by a Chemoenzymic Method
Hill, Jason M.,Hutchinson, Edward J.,Grand, Darren M. Le,Roberts, Stanley M.,Thorpe, Andrew J.,Turner, Nicholas J.
, p. 1483 - 1488 (2007/10/02)
The carboxylic acid 6 was converted into the amine 13 en route to neplanocin-A 9.The same enantiomer of the amine 13 was made from D-ribose ina 13-step synthesis.
Enzyme-catalysed Hydrolysis of Dimethyl 7-Hydroxy-3,3-dimethyl-2,4-dioxabicyclooctane-6,8-dicarboxylate and a Novel Synthesis of Neplanocin A
Hutchinson, Edward J.,Roberts, Stanley M.,Thorpe, Andrew J.
, p. 2245 - 2246 (2007/10/02)
Hydrolysis of the diester 1 catalysed by pig liver esterase provided the mono-ester 3.This ester was converted into the amine 9, a precursor of neplanocin 10, thereby confirming the previously proposed configuration of 3.
