144874-76-0Relevant academic research and scientific papers
Stereoselective Conjugate Addition of Organolithium and Organocopper Reagents to δ-Oxygenated α,β-Unsaturated Carbonyl Systems Derived from Glyceraldehyde Acetonide
Leonard, John,Mohialdin, Soad,Reed, Darrell,Ryan, Gary,Swain, Philip A.
, p. 12843 - 12858 (1995)
Addition reactions of organolithium and organocopper reagents to δ-oxygenated α,β-unsaturated carbonyls, derived from glyceraldehyde acetonide, have been studied.In most cases there is a strong preference for conjugate addition of the organometallic reagent.Organocopper reagents react with anti stereoselectively, whereas most organolithium reagents react with syn stereoselectivity, except for phenyllithium which is unusual.
