1448755-99-4

Basic information

• Product Name: 5-(2,5-dimethoxybenzyl)-7-methoxy-2,2-dimethyl-4H-benzo[d]-[1,3]dioxin-4-one
• Synonyms: 5-(2,5-dimethoxybenzyl)-7-methoxy-2,2-dimethyl-4H-benzo[d]-[1,3]dioxin-4-one
• CAS NO: 1448755-99-4
• Molecular Weight: 358.391
• Mol File: 1448755-99-4.mol

Chemical Properties

• CAS DataBase Reference: 5-(2,5-dimethoxybenzyl)-7-methoxy-2,2-dimethyl-4H-benzo[d]-[1,3]dioxin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,5-dimethoxybenzyl)-7-methoxy-2,2-dimethyl-4H-benzo[d]-[1,3]dioxin-4-one(1448755-99-4)
• EPA Substance Registry System: 5-(2,5-dimethoxybenzyl)-7-methoxy-2,2-dimethyl-4H-benzo[d]-[1,3]dioxin-4-one(1448755-99-4)

Safety Data

• Hazardous Substances Data: 1448755-99-4(Hazardous Substances Data)

Upstream product

• 1448756-07-7 5-(2,5-dimethoxybenzyl)-7-hydroxy-2,2-dimethyl-4H-benzo[d]-[1,3]dioxin-4-one 
• 74-88-4 methyl iodide 

Downstream Products

• 1448756-14-6 methyl 2-(2,5-dimethoxybenzyl)-6-hydroxy-4-methoxybenzoate 

Relevant articles and documents

Synthesis of macrosporin and related 9,10-anthraquinones by biomimetic polyketide aromatization and cyclization of 6-benzylresorcylates

This paper describes the synthesis of an array of 9,10-anthraquinones 2 by initial preparation of 6-benzylresorcylates 3 from oxo-dioxinone precursors 4 and their subsequent conversion to anthrones by cyclization and oxidation. Resorcylates 3 were obtained by an improved two-step procedure from oxo ester 5 and acyl chlorides 6. These methods were applied in a seven-step synthesis of the fungal natural product macrosporin (1). A new synthetic approach to 9,10-anthraquinones was developed. Selective Claisen condensation of an allyl γ-dioxinyl-β-oxo ester with arylacetyl chlorides, Pd-catalyzed deallylation, decarboxylation and aromatization gave 6-(arylmethyl)resorcylates. Subsequent acid-mediated cyclization and oxidation with CAN gave target anthraquinones, one of these being the fungal natural product macrosporin. Copyright