1448775-65-2Relevant academic research and scientific papers
Enantioselective alkylation of aldehydes using functionalized alkylboron reagents catalyzed by a chiral titanium complex
Kumar, Ravindra,Kawasaki, Hiroki,Harada, Toshiro
supporting information, p. 4198 - 4201 (2013/09/12)
A practical method is developed for the synthesis of enantioenriched functionalized secondary alcohols through catalytic enantioselective alkylation of aldehydes. Functionalized alkylboron reagents, [FG-(CH2) n]3B (FG = Br, TIPSO, PhtN, CO2iPr, and CN) prepared from terminal olefin precursors by hydroboration, undergo enantioselective addition to aldehydes in the presence of a catalytic amount (5 mol %) of 3-(3,5-diphenylphenyl)-H8-BINOL and excess titanium tetraisopropoxide to afford the corresponding functionalized alcohols in high enantioselectivities up to 99% ee.
