1448809-07-1

Basic information

• Product Name: 2-(iodomethylene)-1-tosyl-1H-benzo[f]indol-3(2H)-one
• Synonyms: 2-(iodomethylene)-1-tosyl-1H-benzo[f]indol-3(2H)-one
• CAS NO: 1448809-07-1
• Molecular Weight: 475.307
• Mol File: 1448809-07-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(iodomethylene)-1-tosyl-1H-benzo[f]indol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(iodomethylene)-1-tosyl-1H-benzo[f]indol-3(2H)-one(1448809-07-1)
• EPA Substance Registry System: 2-(iodomethylene)-1-tosyl-1H-benzo[f]indol-3(2H)-one(1448809-07-1)

Safety Data

• Hazardous Substances Data: 1448809-07-1(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 60178-65-6 3-((4-methylphenyl)sulfonamido)-2-naphthoic acid 
• 5959-52-4 2-Amino-3-naphthoic acid 
• 1448808-97-6 1-(2-(tosylamino)naphthalen-3-yl)prop-2-yn-1-ol 
• 34161-90-5 N-(3-formylnaphthalen-2-yl)-4-methylbenzenesulfonamide 
• 675578-51-5 N-(p-toluenesulfonyl)-2-amino-3-hydroxymethylnaphthalene 

Relevant articles and documents

1-(2′-Anilinyl)prop-2-yn-1-ol rearrangement for oxindole synthesis

A synthetic method that relies on NIS (N-iodosuccinimide)-mediated cycloisomerization reactions of 1-(2′-anilinyl)prop-2-yn-1-ols to gem-3-(diiodomethyl)indolin-2-ones and 2-(iodomethylene)indolin-3-ones has been developed. The reactions were shown to be chemoselective, with secondary and tertiary alcoholic substrates exclusively giving the 3- and 2-oxindole products, respectively. In the case of the latter, the transformation features an unprecedented double 1,2-OH and 1,2-alkyl migration relay. Density functional theory (DFT) calculations based on proposed iodoaminocyclization species provide insight into this unique divergence in product selectivity. Copyright