1448811-47-9Relevant academic research and scientific papers
Chlorination of Arylaldehyde-Derived Arylsulfonylhydrazones with N -Chlorosuccinimide Leading to 1,2,4,5-Tetrazine Derivatives
Ji, Yuan-Zhao,Li, Hui-Jing,Liu, Ying,Wu, Yan-Chao
, p. 69 - 74 (2019/12/26)
It has been reported previously that treatment of aryl-ketone-derived arylsulfonylhydrazones with NXS/(n Bu) 4 NX affords exclusively vinyl halides. In contrast, we have found that treatment of aryl-aldehyde-derived arylsulfonylhydrazones with
Novel synthesis of 3,6-disubstituted-1,2,4,5-tetrazine derivatives from hydrazones by using [hydroxyl(tosyloxy)iodo]benzene
Liu, Haixuan,Wei, Yunyang
supporting information, p. 4645 - 4648 (2013/08/23)
A mild and efficient protocol for the construction of 1,4-dihydro-3,6- disubstituted-1,4-bis(p-toluenesulfonyl)-1,2,4,5-tetrazines from p-toluenesulfonyl hydrazones mediated by [hydroxyl(tosyloxy)iodo]benzene in the presence of pyridine has been developed. This protocol affords the products in good to excellent yields. The corresponding 3,6-disubstituted-1,2,4,5-tetrazines can be easily obtained through one-step N-deprotection of p-toluensulfonyl groups and aromatization by tetrabutyl ammonium fluoride in THF. A mechanism has been proposed.
