1448818-74-3Relevant academic research and scientific papers
Catalytic highly asymmetric 1,5(6)-selective cyclization reaction of α-hydroxyimino cyclic ketones: Direct approach to ring-fused hydroxyimino dihydropyrans
Liu, Luping,Zhang, Dekui,Zhang, Panpan,Jiang, Xianxing,Wang, Rui
, p. 5222 - 5225 (2013/08/23)
Herein, we have disclosed a catalytic asymmetric 1,5(6)-selective Michael/cyclization reaction of α-hydroxyimino cyclic ketones with γ,β-unsaturated α-keto esters. Unlike the previous catalytic strategies, this reaction provides a convenient 1,5(6)-selective asymmetric pathway to access synthetically useful ring-fused dihydropyrans. In general, high levels of yield, enantio- and diastereoselectivity (up to 99% yield, >99% ee and >20:1 dr) were obtained.
